J. Cancer Mol. 4: 99-108, 2008

[Review Article]

Multi-Chaperones-Interactors Network in Mitochondria (MtCIN): Its Role in Carcinogenesis and Methodology of Analysis

Anna M. Czarnecka, Jerzy S. Czarnecki, Anna Ribbene, and Francesco Cappello

Postgraduate School of Molecular Medicine, Medical University of Warsaw, and Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Warszawa, Poland [A. M. Czarnecka]; Department of Management, Faculty of Management, University of Lodz, Poland [J. S. Czarnecki]; Human Anatomy Section, Department of Experimental Medicine, University of Palermo, Palermo, Italy [A. Ribbene; F. Cappello]

Abstract:

In human mitochondria, the characterization of multiple functional and structural interactions of mitochondrial chaperones is needed for the understanding of the cellular protein biogenesis as well as of the process of carcinogenesis.  In light of current available data, we propose that mitochondrial Hsp70, Hsp60/10, DnaJ-like proteins, GrpE-like proteins, Clp/Hsp100, and Hsp90 families should be analyzed as a part of multi-chaperones-interactors network, and that single protein-protein interaction analysis does not constitute sufficient explanatory framework of carcinogenic potential of mitochondrial chaperones.  We also believe that new chaperones and cell-cycle regulatory interactors are to be defined in the near future, but many technical and methodological efforts are needed before any generalization of the data will be possible and a reliable map of multi-chaperones-interactors network will be constructed.

Received 10/29/07; Revised 6/25/08; Accepted 8/9/08.

¹Correspondence: Dr. Anna M. Czarnecka, Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, ul. Pawinskiego 5a, 02-106 Warszawa, Poland. Fax: 48-42-6508929. E-mail: anna.czarnecka@gmail.com

²Abbreviations: HSP (Hsp), heat shock protein; mtHsp70, mitochondrial Hsp70; MtCIN, mitochondrial multi-chaperones-interactors network; VDAC, voltage-dependent anion channel; mtDNA, mitochondrial DNA.

Hyperlink to Full Text [PDF (720 KB)]