Cancer Mol. 4: 99-108, 2008
Network in Mitochondria (MtCIN): Its Role in Carcinogenesis and
Methodology of Analysis
M. Czarnecka, Jerzy S. Czarnecki, Anna Ribbene, and Francesco Cappello
School of Molecular Medicine, Medical University of Warsaw, and
Institute of Genetics and Biotechnology, Faculty of Biology, University
Warszawa, Poland [A. M.
Department of Management, Faculty of Management, University of Lodz,
Poland [J. S.
Human Anatomy Section, Department of Experimental Medicine, University
of Palermo, Palermo, Italy [A.
Ribbene; F. Cappello]
human mitochondria, the characterization of multiple functional and
structural interactions of mitochondrial chaperones is needed for the
understanding of the cellular protein biogenesis as well as of the
process of carcinogenesis. In light of current available data, we
propose that mitochondrial Hsp70, Hsp60/10, DnaJ-like proteins, GrpE-like
proteins, Clp/Hsp100, and Hsp90 families should be analyzed as a part of
multi-chaperones-interactors network, and that single protein-protein
interaction analysis does not constitute sufficient explanatory
framework of carcinogenic potential of mitochondrial chaperones. We
also believe that new chaperones and cell-cycle regulatory interactors
are to be defined in the near future, but many
technical and methodological efforts
are needed before any generalization of the data will be possible and a
reliable map of multi-chaperones-interactors network will be
mtHsp70; Hsp60; p53; pro-caspase-3)
Received 10/29/07; Revised
6/25/08; Accepted 8/9/08.
Dr. Anna M. Czarnecka,
Institute of Genetics and Biotechnology,
Faculty of Biology, University of Warsaw, ul.
5a, 02-106 Warszawa, Poland.
Fax: 48-42-6508929. E-mail:
HSP (Hsp), heat shock protein; mtHsp70,
mitochondrial Hsp70; MtCIN, mitochondrial multi-chaperones-interactors
network; VDAC, voltage-dependent anion channel;
mtDNA, mitochondrial DNA.
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