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CALL FOR PAPERS Publish your paper in color without any page charge ! Journal of Cancer Molecules is published bimonthly by MedUnion Press. All papers are free to download ! More than 22000 cancer researchers throughout the world can receive the Journal hard prints or contents alerts. Journal of Cancer Molecules was launched in October 2005, and is now indexed by CAplus, Google Scholar, TEPS, CEPS, Sirus, EMBASE, etc. Journal of Cancer Molecules is published bimonthly by MedUnion Press. All papers are free to download. CALL FOR PAPERS Publish your paper in color without any page charge !

Print ISSN: 1816-0735 Online ISSN: 1817-4256

AIM & SCOPE

Journal of Cancer Molecules publishes peer-reviewed reviews and original papers concerned with basic research and clinical practice in the molecular aspects of cancer. Research areas covered in the Journal include: cancer genomics and proteomics, tumor markers and clinical molecular correlates, molecular carcinogenesis, structures of cancer-related molecules, development of therapeutic molecules, and molecular pharmacology. Specially, the Journal encourages the reports of clinical therapies against molecular targets.

This journal is indexed/covered by: CAplus, CEPS, TEPS, Sirus, Scopus, EMBASE, Google Scholar, DOAJ, etc.

In this Journal.....

miRNAs in human cancers [4(3): 79-89][3(5): 133-138]

Cancer as a "Mitochondriopathy"

Cys-Oxidation [3(2): 37-43 / 2(1): 9-16]: Emerging roles of cys-oxidation in regulating proteins involved in cell signaling and tumor malignancy.

Potential Target for Anti-Cancer Therapy: Cathepsin S inhibitors summarized in 3(1): 5-14

Online movies:

Volume 2 Number 4 / Online supplement

(Movie) Tumor-Associated Macrophages Induce Vascular Endothelial Cell Capillary Tube and Network Formation

Volume 2 Number 3 / Online supplement

(Movie) Tumor-Associated Macrophages: Frontiersmen of Tumor Spreading

For more melanoma research information, please go to The Melanoma Molecular Map Project (MMMP), an open-access multi-database dedicated to the research on melanoma biology and therapy....

[Cover Caption]

In Volume 4 Number 4:

Organisms have developed a number of different strategies to cope with unfavorable changes in their environment. The stress responses are characterized by a rapid increase in the expression of a selected group of proteins, termed “molecular chaperones”, that protect cells and the whole organism from severe damage. Although until today many researchers investigated the roles of molecular chaperones in the processes of apoptosis and tumorigenesis, most of the studies have been performed on single protein-protein interaction but not on multiple chaperone-chaperone or chaperone-interactors networks. In this issue, Czarnecka et al. suggest that analysis of multi-protein complexes would reflect the situation in vivo to a large degree and could better represent the dynamic complexity, displayed by biological systems. Understanding of the hierarchical structure and multi-dimensional protein network of biological system is key to the understanding of its physiology and development. For details, please read the review article [4(4): 99-108].

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Review Article

Multi-Chaperones-Interactors Network in Mitochondria (MtCIN): Its Role in Carcinogenesis and Methodology of Analysis / 4(4): 99-108 / by Anna M. Czarnecka, Jerzy S. Czarnecki, Anna Ribbene, and Francesco Cappello

Research Papers

Eurycomanone Induces Apoptosis through the Up-Regulation of p53 in Human Cervical Carcinoma Cells / 4(4): 109-115 / by Nurkhasanah Mahfudh and Azimahtol Hawariah Lope Pihie

Screening of Trichostatin Analogues Based on Cellular Potency in the Murine Multiple Myeloma 5T33MM Model / 4(4): 117-121 / by Sarah Deleu, Joanna Fraczek, Aneta Lukaszuk, Tatyana Doktorova, DirkTourwé, Albert Geerts, Ben Van Camp, Tamara Vanhaecke, Vera Rogiers, and Karin Vanderkerken

Methylation Profiles of hMLH1 Proximal Promoter in Colorectal Tumor Progression / 4(4): 123-127 / by Romain Marignol, Jeanne Ramos, Pascal Pujol, Thierry Maudelonde, and Jean-Marc Rey

Recently Published Papers

RNA Interference – Regulations and Application in Oncology / 4(3): 67-77 / by Dragomira Nikolova and Draga Toncheva

Great Potential of MicroRNA in Cancer Stem Cell / 4(3): 79-89 / by MicroGene H. P. Xia

Abnormal Expression of Hepatic Transforming Growth Factor-beta1 at the Early Stage of Hepatocellular Carcinoma Formation / 4(3): 91-96 / by Zhizhen Dong, Dengfu Yao, Yilang Wang, Junjun Shen, Chongguo Zhang, Hua Huang, Liwei Qiu, Wei Wu, and Xinhua Wu

Anti-Angiogenic Therapeutic Drugs for Treatment of Human Cancer / 4(2): 37-45 / by Han-Chung Wu, Chia-Ting Huang, and De-Kuan Chang

Analysis of Cytotoxic Effects of Chemotherapeutic Agents on Lung and Small Intestinal Neuroendocrine Cell Lines / 4(2): 47-54 / by Jan Bornschein, Mark Kidd, Maximilian V. Malfertheiner, Ignat Drozdov, Roswitha Pfragner, and Irvin M. Modlin

Phosphatidylinositol 3-Kinase and NF-kB Involved in Epidermal Growth Factor-Induced Matrix Metalloproteinase-9 Expression / 4(2): 55-60 / by Shuvojit Moulik, Triparna Sen, Anindita Dutta, Aniruddha Banerji, Chinmoy Ghosh, Shamik Das, and Amitava Chatterjee

Mesenchymal Stem Cells and Cancer — for Better or for Worse? / 4(1): 5-9 / by B. Linju Yen and Men-Luh Yen

Curcumin: a Potential Cancer Chemopreventive Agent through Suppressing NF-kB Signaling / 4(1): 11-16 / by Chih-Li Lin and Jen-Kun Lin

Proteins Expressed on Tumor Endothelial Cells as Potential Targets for Anti-Angiogenic Therapy / 4(1): 17-22 / by Han-Chung Wu and Pi-Chun Li

Clinical Response of Gefitinib on Malignant Pleural Effusions in Patients with Non-Small Cell Lung Cancer / 4(1): 23-28 / by Chi-Hsien Chen, Chien-Hung Gow, Chong-Jen Yu, Jin-Yuan Shih, Ya-Chieh Hsu, Wen-Yu Lee, Pan-Chyr Yang, and Sow-Hsong Kuo

Epigenetic Regulation of EpCAM in Tumor Invasion and Metastasis / 3(6): 165-168 / by Shine-Gwo Shiah, Kang-Yu Tai, and Cheng-Wen Wu

Expression and Prognostic Significance of EpCAM / 3(6): 169-174 / by Philip Went, Stephan Dirnhofer, Daniel Schöpf, Holger Moch, and Gilbert Spizzo

Serum Levels of Apolipoprotein A-II as a Potential Marker for Cholangiocarcinoma / 3(6): 175-181 / by Xiaomin Wang, Anjian Xu, Bo Liu, Juling Wang, Liyun Liu, Songwei Dai, Xueyuan Xiao, and Dacheng He [Comment on this paper]

MicroRNA: A New Player in Breast Cancer Development / 3(5): 133-138 / by Vivien Wang and Wei Wu

Intercalating and Antitumour Activity of 4-Oxopyrimido[4',5':4,5]thieno(2,3-b)-quinoline-4(3H)-one / 3(5): 139-146 / by M. S. Shahabuddin, M. Gopal, and Sathees C. Raghavan

Anti-tumor Effect of Doxycycline on Glioblastoma Cells / 3(5): 147-153 / by Andrea Wang-Gillam, Eric Siegel, Debra A. Mayes, Laura F. Hutchins, and Yi-Hong Zhou

Targeted mTOR in Human Gynecologic Cancers / 3(4): 101-106 / by Yi-Jen Chen

Elevation of Serum HSP90alpha Correlated with the Clinical Stage of Non-Small Cell Lung Cancer / 3(4): 107-112 / by Anjian Xu, Tian Tian, Jia Hao, Jifu Liu, Zhao Zhang, Juanting Hao, Shanshan Wu, Lingyun Huang, Xueyuan Xiao, and Dacheng He

Insulin and Epidermal Growth Factor’s Activation of Extracellular-Signal Regulated Kinases 1/2 and DNA Synthesis Is Inhibited by Four Cardiac Hormones / 3(4): 113-120 / by Ying Sun, Ehrentraud J. Eichelbaum, Hai Wang, and David L. Vesely

Curcumin and Quercetin Combined with Cisplatin to Induce Apoptosis in Human Laryngeal Carcinoma Hep-2 Cells through the Mitochondrial Pathway / 3(4): 121-128 / by Meenakshi Kuhar, Sabiha Imran, and Neeta Singh [Comment on this paper]

Cancer as a "Mitochondriopathy" / 3(3): 71-79 / by Anna M Czarnecka, Antonella Marino Gammazza, Valentina Di Felice, Giovanni Zummo, and Francesco Cappello

Induction of FADD Expression and Caspase Cascades Involved in RC-RNase-Induced Apoptosis in Human Cervical Cancer Cells / 3(3): 81-89 / by Huey-Chung Huang, You-Di Liao, Li-Li Chen, and Tze-Sing Huang

RNA Interference against MDR1 but not MRP1 Reverses Drug Resistance in Human Small-Cell Lung Cancer Cells / 3(3): 91-94 / by David Sadava and Wendy Hamman

Targeting the Nrf2-Prx1 Pathway with Selenium to Enhance the Efficacy and Selectivity of Cancer Therapy / 3(2): 37-43 / by Yun-Jeong Kim, Sun-Hee Baek, Paul N. Bogner, Clement Ip, Youcef M. Rustum, Marwan G. Fakih, Nithya Ramnath, and Young-Mee Park

The Role of Enolase in Tissue Invasion and Metastasis of Pathogens and Tumor Cells / 3(2): 45-48 / by Ko-Jiunn Liu and Neng-Yao Shih

In Vivo Effects of Cyclooxygenase-2 Deletion on Cellular Signaling in Hepatocellular Carcinoma Xenografts in Nude Mice / 3(2): 49-54 / by Wei Cui, Shirley X Hu, Zhen-Ya Tang, and Ke-Qin Hu

Dendritic Cells Pulsed with Irradiated Prostate Tumor Cells Express CC Receptor-7 and Its Ligands and Initiate a Tumor Specific Immune Response / 3(2): 55-60 / by Prabir K. Chakravarty, Giridhar R. Gorla, Zoya Niazova, and Bhadrasain Vikram

Lysosomal Cysteine Proteinase Cathepsin S as a Potential Target for Anti-Cancer Therapy / 3(1) 5-14 / by Wun-Shaing W. Chang, Hsin-Ru Wu, Chi-Tai Yeh, Cheng-Wen Wu, and Jang-Yang Chang

**Antitumor Activity of Combination Treatment of Lentinus edodes Mycelium Extracts with 5-Fluorouracil against Human Colon Cancer Cells Xenografted in Nude Mice** / 3(1) 15-22 / by Chih-Hsiung Wu, Chi-Chen Wu, and Yuan-Soon Ho

Effects of Platinum Derivatives on the Function and Expression of P-Glycoprotein/MDR1 in LLC-PK₁ Cells: In the Cases of Carboplatin and Nedaplatin / 3(1) 23-28 / by Noriaki Kitada, Kohji Takara, Masayuki Tsujimoto, Toshiyuki Sakaeda, Noriaki Ohnishi, and Teruyoshi Yokoyama

Glioblastoma in a Patient with Professional Exposure to the Oncogenic Polyomavirus SV40 / 3(1) 29-32 / by Fernanda Martini, Veronica Balatti, Francesco Lupidi, Massimo Gerosa,and Mauro Tognon

Dendritic Cell, Toll-Like Receptor, and The Immune System / 2(6) 213-215 / by Ko-Jiunn Liu

Current Progress in Dendritic Cell Research / 2(6) 217-220 / by Ko-Jiunn Liu and Ching-Liang Chu

Induction of Significant Cytotoxic Activity for Autologous Leukemia Cells: Inverse Correlation between Cytotoxicity and FOXP3 mRNA Expression / 2(6) 221-226 / by Yasuki Hijikata, Yasuhiro Maeda, Terufumi Yamaguchi, Yasuyoshi Morita, Miyako Tanaka, Chikara Hirase, Shunsuke Takai, Yoichi Tatsumi, and Akihisa Kanamaru

Tumor 5-Lipoxygenase Expression Correlates with Gastric Cancer Metastasis and Its Selective Inhibitor Induces Cancer Cell Apoptosis / 2(6) 227-233 / by Lai-Yu Zou, Jian-Ying Li, Feng-Lin Chen, Zhi-Xin Chen, and Xiao-Zhong Wang

Matrix-Degrading Type II Transmembrane Serine Protease Matriptase: Its Role in Cancer Development and Malignancy 2(5) 183-190 [Abstract] [PDF (1.2 MB)] / by Ming-Shyue Lee

Roles of p53 in Carcinogenesis, Diagnosis and Treatment of Hepatocellular Carcinoma 2(5) 191-197 [Abstract] [PDF (636 KB)] / by Yong-Song Guan, Qing He, and Zi La

Sesamin inhibits Vascular Endothelial Cell Growth and Angiogenic Activity of Lung Adenocarcinoma Cells 2(5) 199-205 [Abstract] [PDF (1.9 MB)] / by Shiow-Chwen Tsai, Ya-Chen Liu, Chung-Pin Li, Tze-Sing Huang, and Chun-Chung Lee

Tumor-Associated Macrophage: Its Role in Tumor Angiogenesis 2(4) 135-140 [Abstract] [PDF (1.1MB)] / by Chun-Chung Lee, Ko-Jiunn Liu, and Tze-Sing Huang

p53: Structure, Function and Therapeutic Applications 2(4) 141-153 [Abstract] [PDF (1.3MB)] / by Ling Bai and Wei-Guo Zhu

Tumor Necrosis Factor-alpha, Interleukin-8 and Interleukin-6 Are Involved in Vascular Endothelial Cell Capillary Tube and Network Formation Induced by Tumor-Associated Macrophages 2(4) 155-160 [Abstract] [PDF (1.4MB)] / by Chun-Chung Lee, Ko-Jiunn Liu, Li-Li Chen, Yu-Chen Wu, and Tze-Sing Huang

Prognostic Significance of Vascular Endothelial Growth Factor-A Expression in Colorectal Cancer 2(4) 161-167 [Abstract] [PDF (880KB)] / by Yalcin Kekec, Semra Paydas, Suzan Zorludemir, Cem Kaan Parsak, Gurhan Sakman, and Gulsah Seydaoglu

Online supplement (J. Cancer Mol. 2: S2, 2006): [Movie]: Tumor-Associated Macrophages Induce Vascular Endothelial Cell Capillary Tube and Network Formation [http://www.mupnet.com/JOCM 2(4)movie.htm] / by Chun-Chung Lee, Ko-Jiunn Liu and Tze-Sing Huang

Tumor-Associated Macrophage: Its Role in Cancer Invasion and Metastasis 2(3) 101-106 [Abstract][HTML (168 KB)] [PDF (664 KB)] / by Jin-Yuan Shih, Ang Yuan, Jeremy J.-W. Chen, and Pan-Chyr Yang

Altered Sialylation and Its Roles in Gynecologic Cancers 2(3) 107-116 [Abstract][HTML (416 KB)] [PDF (748 KB)] / by Peng-Hui Wang

RASSF2 Induces Activated Ras-Dependent Cell Growth Inhibition and Apoptosis in Human Pancreatic Cancer Cells 2(3) 117-122 [Abstract][HTML (108 KB)] [PDF (1.2 MB)] / by Jing-Hua Ren, Ju-ShengLin, Wen-Shan He, Xue-Mei Sun, Pei-Yuan Li, Ying Chang, Yao Liu, Chao Li, and Xin-Sheng Gao

Low Frequency of 185delAG Founder Mutation of BRCA1 Gene in Iranian Breast Cancer Patients 2(3) 123-127 [Abstract][HTML (160 KB)] [PDF (456 KB)] / by Parvin Mehdipour, Saied Hosseini-Asl, Arezoo Savabi-E, Laleh Habibi, Ehsan Alvandi, and Morteza Atri

Online supplement (J. Cancer Mol. 2: S1, 2006): [Movie] Tumor-Associated Macrophages: Frontiersmen of Tumor Spreading [http://www.mupnet.com/JOCM2(3)movie.htm] / by Huey-Chung Huang, Chun-Chung Lee, and Tze-Sing Huang

Targeted Therapy for Cancer 2(2): 57-66 [Abstract] [HTML (644 KB)] [PDF (912 KB)] / by Han-Chung Wu, De-Kuan Chang, and Chia-Ting Huang

Cathepsin B and Cysteine Protease Inhibitors in Human Tongue Cancer: Correlation with Tumor Staging and In Vitro Inhibition of Cathepsin B by Chicken Cystatin 2(2): 67-72 [Abstract] [HTML (196 KB)] [PDF (2.7 MB)] / by Yousif Saleh, Jan Wnukiewicz, Ryszard Andrzejak, Tadeusz Trziszka, Maciej Siewinski,Piotr Ziolkowski, and Wieslaw Kopec

Expression of Heat Shock Proteins HSP10, HSP27, HSP60, HSP70, and HSP90 in Urothelial Carcinoma of Urinary Bladder 2(2): 73-77 [Abstract] [HTML (184 KB)] [PDF (3.1 MB)] / by Francesco Cappello, Sabrina David, Nella Ardizzone, Francesca Rappa, Lorenzo Marasà, Fabio Bucchieri, and Giovanni Zummo

Two-Phased Alteration and Clinical Relevance of MTA1 and MTA1s Gene Expression: A Quantitative PCR Analysis in Breast Cancer Patients 2(2): 79-84 [Abstract] [HTML (352 KB)] [PDF (452 KB)] / by Kung-Chia Young, Ching-Ting Huang, Shoei-Loong Lin, and Wei-Chiang Hsiao

Cys-Oxidation of Protein Tyrosine Phosphatases: Its Role in Regulation of Signal Transduction and Its Involvement in Human Cancers 2(1): 9-16 [Abstract] [PDF (1.19 MB)] / by Tzu-Ching Meng, Yi-Wei Lou, Yi-Yun Chen, Shu-Fang Hsu, and Yi-Fen Huang

Comparative Proteomics of Colorectal Cancer: Abnormal Expression of Proteins within the Tumor Nest and Implication of HnRNP A1 as an Oncoprotein in Tumorigenesis 2(1): 17-24 [Abstract] [HTML (0.2 MB)] [PDF (57.5 MB)] / by DaoHai Zhang, Lee Kian Tai, Ming Teh, Sunil K. Sethi, and Evelyn S. C. Koay

Histone Deacetylase-Inhibitors Sensitize Human Prostate Cancer Cell Lines to Growth Suppression and Apoptosis by Retinoids 2(1): 25-36 [Abstract] [PDF (5.72 MB)] / by Jian Gu, Xianshi Zhao, Remco A. Spanjaard, Tai C. Chen, John N. Flanagan, Michael Boosalis, Susan P. Perrine, and Douglas V. Faller

In Vivo Evaluation of Combination Use of Two Radiosensitizers Iododeoxyuridine and Misonidazole: A Biodistribution Study with Whole-Body Autoradiography 2(1): 37-43 [Abstract] [PDF (2.33 MB)] / by Jeng-Jong Hwang, Hsin-Ell Wang, Hsin-Yu Fang, Fu-Du Chen, Frank Q. H. Ngo

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