Print ISSN: 1816-0735         Online ISSN: 1817-4256


   Journal of Cancer Molecules publishes peer-reviewed reviews and original papers concerned with basic research and clinical practice in the molecular aspects of cancer.  Research areas covered in the Journal include: cancer genomics and proteomics, tumor markers and clinical molecular correlates, molecular carcinogenesis, structures of cancer-related molecules, development of therapeutic molecules, and molecular pharmacology.  Specially, the Journal encourages the reports of clinical therapies against molecular targets.

Volume 2 Number 4 / Online supplement

Tumor-Associated Macrophages Induce Vascular Endothelial Cell Capillary Tube and Network Formation

JOCM 2(2) 57-66.pdf 

JOCM 2(3) 101-106.pdf 

Volume 2 Number 3 / Online supplement

Tumor-Associated Macrophages: Frontiersmen of Tumor Spreading 

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[Cover Caption]

Volume 2   Number 5    (October 17, 2006)

   Matriptase is a type II transmembrane serine protease.  Through HAI-1, the matriptase activity is well regulated.  An imbalance between matriptase and HAI-1 levels results in abnormal matriptase activation, contributing to cancer development and malignant progression.  Matriptase-activated HGF or PAR-2 could promote tumor cell growth and survival through the c-Met receptor or the G-protein-coupled receptor signal pathway.  Furthermore, HGF induces cell mobility and coordinates with the matriptase-activated uPA/plasmin system to facilitate cancer cell invasion by degrading extracellular matrix.  

For details, please see the review paper ([PDF (1.2 MB)]) published in this issue.

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Review Articles

Matrix-Degrading Type II Transmembrane Serine Protease Matriptase: Its Role in Cancer Development and Malignancy 2(5) 183-190 [Abstract] [PDF (1.2 MB)] / by Ming-Shyue Lee

Roles of p53 in Carcinogenesis, Diagnosis and Treatment of Hepatocellular Carcinoma 2(5) 191-197 [Abstract] [PDF (636 KB)] / by Yong-Song Guan, Qing He, and Zi La

Research Papers

Sesamin inhibits Vascular Endothelial Cell Growth and Angiogenic Activity of Lung Adenocarcinoma Cells 2(5) 199-205 [Abstract] [PDF (1.9 MB)] / by Shiow-Chwen Tsai, Ya-Chen Liu, Chung-Pin Li, Tze-Sing Huang, and Chun-Chung Lee

Recently Published Papers

Tumor-Associated Macrophage: Its Role in Tumor Angiogenesis 2(4) 135-140 [Abstract] [PDF (1.1MB)] / by  Chun-Chung Lee, Ko-Jiunn Liu, and Tze-Sing Huang

p53: Structure, Function and Therapeutic Applications 2(4) 141-153 [Abstract] [PDF (1.3MB)] / by  Ling Bai and Wei-Guo Zhu

Tumor Necrosis Factor-alpha, Interleukin-8 and Interleukin-6 Are Involved in Vascular Endothelial Cell Capillary Tube and Network Formation Induced by Tumor-Associated Macrophages 2(4) 155-160 [Abstract] [PDF (1.4MB)] / by Chun-Chung Lee, Ko-Jiunn Liu, Li-Li Chen, Yu-Chen Wu, and Tze-Sing Huang

Prognostic Significance of Vascular Endothelial Growth Factor-A Expression in Colorectal Cancer 2(4) 161-167 [Abstract] [PDF (880KB)] / by Yalcin Kekec, Semra Paydas, Suzan Zorludemir, Cem Kaan Parsak, Gurhan Sakman, and Gulsah Seydaoglu

Online supplement (J. Cancer Mol. 2: S2, 2006): [Movie]: Tumor-Associated Macrophages Induce Vascular Endothelial Cell Capillary Tube and Network Formation [ 2(4)movie.htm] / by Chun-Chung Lee, Ko-Jiunn Liu and Tze-Sing Huang

Tumor-Associated Macrophage: Its Role in Cancer Invasion and Metastasis 2(3) 101-106 [Abstract][HTML (168 KB)] [PDF (664 KB)] / by Jin-Yuan Shih, Ang Yuan, Jeremy J.-W. Chen, and Pan-Chyr Yang

Altered Sialylation and Its Roles in Gynecologic Cancers 2(3) 107-116 [Abstract][HTML (416 KB)] [PDF (748 KB)] / by Peng-Hui Wang

RASSF2 Induces Activated Ras-Dependent Cell Growth Inhibition and Apoptosis in Human Pancreatic Cancer Cells 2(3) 117-122 [Abstract][HTML (108 KB)] [PDF (1.2 MB)] / by Jing-Hua Ren, Ju-Sheng Lin, Wen-Shan He, Xue-Mei Sun, Pei-Yuan Li, Ying Chang, Yao Liu, Chao Li, and Xin-Sheng Gao

Low Frequency of 185delAG Founder Mutation of BRCA1 Gene in Iranian Breast Cancer Patients 2(3) 123-127 [Abstract][HTML (160 KB)] [PDF (456 KB)] / by Parvin Mehdipour, Saied Hosseini-Asl, Arezoo Savabi-E, Laleh Habibi, Ehsan Alvandi, and Morteza Atri

Online supplement (J. Cancer Mol. 2: S1, 2006): [Movie] Tumor-Associated Macrophages: Frontiersmen of Tumor Spreading [] / by Huey-Chung Huang, Chun-Chung Lee, and Tze-Sing Huang

Targeted Therapy for Cancer 2(2): 57-66 [Abstract] [HTML (644 KB)] [PDF (912 KB)] / by Han-Chung Wu, De-Kuan Chang, and Chia-Ting Huang

Cathepsin B and Cysteine Protease Inhibitors in Human Tongue Cancer: Correlation with Tumor Staging and In Vitro Inhibition of Cathepsin B by Chicken Cystatin 2(2): 67-72 [Abstract] [HTML (196 KB)] [PDF (2.7 MB)] / by Yousif Saleh, Jan Wnukiewicz, Ryszard Andrzejak, Tadeusz Trziszka, Maciej Siewinski, Piotr Ziolkowski, and Wieslaw Kopec

Expression of Heat Shock Proteins HSP10, HSP27, HSP60, HSP70, and HSP90 in Urothelial Carcinoma of Urinary Bladder 2(2): 73-77 [Abstract] [HTML (184 KB)] [PDF (3.1 MB)] / by Francesco Cappello, Sabrina David, Nella Ardizzone, Francesca Rappa, Lorenzo Marasà, Fabio Bucchieri, and Giovanni Zummo

Two-Phased Alteration and Clinical Relevance of MTA1 and MTA1s Gene Expression: A Quantitative PCR Analysis in Breast Cancer Patients 2(2): 79-84 [Abstract] [HTML (352 KB)] [PDF (452 KB)] / by Kung-Chia Young, Ching-Ting Huang, Shoei-Loong Lin, and Wei-Chiang Hsiao

Cys-Oxidation of Protein Tyrosine Phosphatases: Its Role in Regulation of Signal Transduction and Its Involvement in Human Cancers 2(1): 9-16 [Abstract] [PDF (1.19 MB)]  / by Tzu-Ching Meng, Yi-Wei Lou, Yi-Yun Chen, Shu-Fang Hsu, and Yi-Fen Huang

Comparative Proteomics of Colorectal Cancer: Abnormal Expression of Proteins within the Tumor Nest and Implication of HnRNP A1 as an Oncoprotein in Tumorigenesis 2(1): 17-24 [Abstract] [HTML (0.2 MB)] [PDF (57.5 MB)]   / by DaoHai Zhang, Lee Kian Tai, Ming Teh, Sunil K. Sethi, and Evelyn S. C. Koay

Histone Deacetylase-Inhibitors Sensitize Human Prostate Cancer Cell Lines to Growth Suppression and Apoptosis by Retinoids 2(1): 25-36 [Abstract] [PDF (5.72 MB)]   / by Jian Gu, Xianshi Zhao, Remco A. Spanjaard, Tai C. Chen, John N. Flanagan, Michael Boosalis, Susan P. Perrine, and Douglas V. Faller

In Vivo Evaluation of Combination Use of Two Radiosensitizers Iododeoxyuridine and Misonidazole: A Biodistribution Study with Whole-Body Autoradiography  2(1): 37-43   [Abstract] [PDF (2.33 MB)]   / by Jeng-Jong Hwang, Hsin-Ell Wang, Hsin-Yu Fang, Fu-Du Chen, Frank Q. H. Ngo

Altered Glycosylation in Cancer: Sialic Acids and Sialyltransferases  1(2): 73-81 [Abstract] [PDF (1.26 MB)] / by Peng-Hui Wang

Clinical Application of Epidermal Growth Factor Receptor–Tyrosine Kinase Inhibitors against Non-Small Cell Lung Cancer  1(2): 83-91 [Abstract] [PDF (0.98 MB)] / by Yuh-Min Chen

Characterization of De Novo Genomic Alterations in HBV-Producing Hepatoma Cells Using Array Comparative Genomic Hybridization  1(2): 93-98 [Abstract] [PDF (1.75 MB)] / by Chia-Huei Lee, Qing-Dong Ling, and Mei-Hwei Chang

Correlation of Mammographical Imaging Signs with Expression of Bcl-2 and Bax Proteins in Breast Cancer  1(2): 99-102 [Abstract] [PDF (3.04 MB)] / by Yi-Li Zhang, Sheng-Li Wu, Hong-Wen Du, Yun Zhang, You-Min Guo

Activation of Initiator Caspases: History, Hypotheses, and Perspectives 1(1): 9-18 [Abstract] [PDF (1.18 MB)] / by Yigong Shi

Application of siRNA Library in High-Throughput Genetic Screens of Mammalian Cells  1(1): 19-24 [Abstract] [PDF (507 KB)] / by Li-Na Zhao, Ting-Ting Li, Yang-Lin Pan, Han-Bing Ning, Zhi-Guo Liu, and Dai-Ming Fan

Plasminogen Activator Inhibitor-1: The Expression, Biological Functions, and Effects on Tumorigenesis and Tumor Cell Adhesion and Migration 1(1): 25-36 [Abstract] [PDF (1.74 MB)] / by Chun-Chung Lee and Tze-Sing Huang

Involvement of Intrinsic and Extrinsic Apoptotic Pathways in Baicalein-Induced Apoptosis in Human Hepatoma Hep3B Cells 1(1): 37-45 [Abstract] [PDF (6.96 MB)] / by Yan-Nian Chen, Chi-Chih Cheng, Chang-Tze R. Yu, Su-Jen Chou, Hong-Chen Chen, and Shih-Lan Hsu

Prognostic Significance of Elevated Cyclin B1 Expression in Colorectal Cancer: A Rapid Tissue Lysis and Immunoblot Study 1(1): 47-51 [Abstract] [PDF (235 KB)] / by Jinn-Shiun Chen, Wei-Shone Chen, Jacqueline M. Liu, Jui-Ting Chang, and Tze-Sing Huang

A Successful Treatment with Repeated Surgery and Adjuvant Combination Chemotherapy on a Case of Advanced Undifferentiated Embryonal Sarcoma of Liver 1(1): 53-57 [Abstract] [PDF (2.01 MB)] / by Yang-Hsien Fu, Yee Chao, Cheng-Yuan Hsia, Chung-Pin Li, Rheun-Chuan Lee, Wei-Ping Lee, Jeng-Nian Yuan, Shyh-Haw Tsay, Kwan-Hwa Chi, Sang-Hue Yen, and Wing-Yiu Lui